The Effect of Inhalation Anesthetics on the Requirement of Muscle Relaxants During General Anesthesia in Elderly Patients

Effects of Different Concentrations of Sevoflurane on Intraoperative Cisatracurium Muscle Relaxation Effect in Elderly Patients Undergoing Total Knee Replacement Surgery with General Anesthesia Combined with Nerve Block

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200055556

Enrollment

Unknown

Registered

2022-01-12

Start date

2022-02-16

Completion date

Unknown

Last updated

2023-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

muscle relaxants

Interventions

Group A:sevoflurane 0%

Group B:sevoflurane 0.7%

Group C:sevoflurane 1.0%

Group D:sevoflurane 1.3%

Eligibility

Sex/Gender

All

Age

65 Years to 79 Years

Inclusion criteria

Inclusion criteria: 1. ASA I-II grade; 2. Age >= 65 years old; 3. No respiratory and circulatory diseases before surgery; 4. No use may affect hemodynamics and other unauthorized drugs before operation; 5. Sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. The patient has liver and kidney dysfunction; 2. Suffering from neuromuscular metabolic disease; 3. Allergy to local anesthetics and muscle relaxants; 4. Failure to sign informed consent; 5. Difficulty in postoperative follow-up; 6. There was an accident during the operation (including hemodynamic disturbance, poor nerve block effect, etc.).

Design outcomes

Primary

Measure	Time frame
Recovery index;	—

Secondary

Measure	Time frame
Blood pressure;Heart rate;	—

Countries

China

Contacts

Public ContactWang Hong

Shanghai General Hospital

wh201071@126.com+86 19821271178

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026