Intraoperative tourniquet pain in knee arthroscopic surgery
Conditions
Interventions
Lidocaine group:10 minutes before tourniquet inflation, lidocaine 1.5 mg / kg was injected intravenously and diluted with 10 ml normal saline at a rate of 1 ml / s.
Normal saline group:10ml normal saline was injected intravenously at a rate of 1ml / s 10 minutes before tourniquet inflation.
Sponsors
Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing knee arthroscopy with tourniquet under daytime selective general anesthesia, ASA I-II; 2. Aged 18 to 65 years; 3. BMI 18-30 kg/m2; 4. Normal communication; 5. Voluntary subjects and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. History of hypertension, peripheral vascular disease, history of diabetes and history of cerebral infarction; 2. History of deep venous thrombosis; 3. Heart, liver or kidney disease; 4. History of allergic reactions or seizures to amide local anesthetics; 5. History of chronic analgesics, opioid addicts and non steroidal anti-inflammatory drugs; 6. Mental history: such as schizophrenia, depression, dementia; 7. The quality of postoperative recovery scale (QoR-15) or visual analogue scale (VAS) were not understood.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of intraoperative tourniquet pain or tourniquet hypertension; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic changes;Changes in interleukin-6 (IL-6) concentration in venous blood samples;Changes in tumor necrosis factor a(TNF-a)concentration in venous blood samples;Use of antihypertensive drugs or heart rate lowering drugs;15-item Quality of Recovery,QoR-15;Pain digital analog score(VAS));hospital stay;Postoperative nausea and vomiting;Use of remedial painkillers and remedial antiemetics;Other complications such as dizziness, hypotension or hypertension; | — |
Countries
China
Contacts
Public ContactLu Yao
Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical University
Outcome results
None listed