Atrial Fibrillation
Conditions
Interventions
CPVI+SVCI group:Circumferential Pulmonary Veins Isolation (CPVI) + Superior Vena Cava Electrical Isolation (SVCI)
CPVI group:Circumferential Pulmonary Veins Isolation (CPVI)
Sponsors
Nanjing Drum Tower Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 75 years; 2. Diagnosed as paroxysmal atrial fibrillation; 3. Willing to sign an informed consent; 4. Willing to undergo surgery and follow-up.
Exclusion criteria
Exclusion criteria: 1. Previous atrial fibrillation catheter radiofrequency ablation (except paroxysmal supraventricular tachycardia); 2. Patients with thrombocytopenia (PLT = 55mm (2d echocardiography, parasternal long axis view); 4. Left atrial thrombus (by transesophageal ultrasound or MSCT); 5. Severe structural heart disease (e.g. moderate to severe mitral regurgitation, dilated cardiomyopathy, hypertrophic cardiomyopathy, severe valvular heart disease); 6. Thyroid dysfunction; 7. Severe hepatic and renal dysfunction (AST or ALT >= 3 times the normal upper limit; SCR > 3.5 mg/dl or CCR < 30 ml/min); 8. History of nearly 3 months of surgical operations; 9. Pregnant women; 10.Life expectancy < 12 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The 1-year post-ablation success rate (no documented atrial fibrillation or other atrial arrhythmia events within 12 months).; | — |
Secondary
| Measure | Time frame |
|---|---|
| Perioperative complications (including stroke, pulmonary vein stenosis, cardiac perforation, esophageal injury, septal nerve palsy, and death);Episodes of atrial arrhythmias (atrial fibrillation or atrial tachycardia) within 1 year after ablation;Rate and load of atrial tachycardia and/or frequent atrial premature in blank phase after ablation;Length of muscular sleeve and diameter of superior vena cava; | — |
Countries
China
Contacts
Public ContactXu Wei, Shen Wenzhi
Nanjing Drum Tower Hospital
Outcome results
None listed