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Clinical significance and efficacy mechanism of transcranial direct current stimulation in the treatment of post-stroke cognitive impairment: a randomized single-blind sham-stimulation controlled clinical trial

Clinical significance and efficacy mechanism of transcranial direct current stimulation in the treatment of post-stroke cognitive impairment: a randomized single-blind sham-stimulation controlled clinical trial

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200055500
Enrollment
Unknown
Registered
2022-01-11
Start date
2022-02-01
Completion date
Unknown
Last updated
2023-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Interventions

Experimental group:Routine training + transcranial direct current stimulation therapy
Control group:Routine training + transcranial direct current sham stimulation

Sponsors

Nanjing Brain Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18-65 years; 2. CT or MRI confirmed stroke (including ischemic and hemorrhagic); 3. Decreased function in any cognitive domain appears and persists 3-6 months after stroke; 4. Montreal cognitive assessment (Montreal cognitive assessment, MoCA) score is <22; 5. All signed the informed consent for treatment.

Exclusion criteria

Exclusion criteria: 1. Patients with cognitive impairment or other neurological diseases that cause cognitive decline in the past, such as Alzheimer's disease, Parkinson's disease and Parkinson's syndrome; 2. Concurrent with other serious physical diseases, with metal implants such as pacemakers installed in the body; 3. Those with severe visual, hearing and language impairments, pregnant or breastfeeding patients; 4. Consciousness disturbance, history of severe mental illness, history of severe epilepsy, etc.; 5. Received tDCS treatment.

Design outcomes

Primary

MeasureTime frame
Montreal Intelligence Scale;Brief Mental State Inventory;Wechsler Memory Scale;Digital Span Test;Trail-Making Test;Number Sign Conversion Test;

Secondary

MeasureTime frame
Fractional Anisotropy;Global Network Efficiency;Local Network Efficiency;Clustering Coefficient;Node Degree;‘’Small world’’ Property;

Countries

China

Contacts

Public ContactWang Yao

Affiliated Brain Hospital of Nanjing Medical University

qy872002@126.com+86 13951817797

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026