The effect of surgery start time on stress response and short-term outcomes in patients undergoing transsphenoidal surgery to remove pituitary adenomas: a prospective, single-center study.

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200055473

Enrollment

Unknown

Registered

2022-01-10

Start date

2022-06-30

Completion date

Unknown

Last updated

2023-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pituitary tumors

Interventions

Group A:Surgery starts before 1pm

Group B:Surgery starts after 1pm

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Patients aged 18-80 years, no gender restrictions; 2. Patients who underwent transsphenoidal pituitary tumor resection by the same skilled neurosurgeon (to avoid operator-related bias); 3. Patients with ASA classification II-III; 4. Patients with pituitary adenomas (to avoid any effect of brain tumors on stress response).

Exclusion criteria

Exclusion criteria: 1. Patients who refuse to participate in or cannot cooperate with the trial due to neuropsychiatric diseases. 2. Patients with primary hyperthyroidism or hypothyroidism. 3. Patients with factors that affect the circadian rhythm of cortisol, such as sleep disturbances or use of psychiatric drugs.

Design outcomes

Primary

Measure	Time frame
cortisol;blood sugar;C-reactive protein;	—

Secondary

Measure	Time frame
intraoperative outcomes;postoperative results;	—

Countries

China

Contacts

Public ContactZhou Zhidong

The Second Affiliated Hospital of Nanchang University

dongdongzhi@163.com+86 13970932882

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026