Biliary atresia
Conditions
Interventions
combined 
diagnostic 
Gold Standard:Biliary tract exploration and liver pathology.
Index test:MMP-7, 
and 
ultrasound 
Sponsors
Pediatric Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged =17umol/L; or serum total bilirubin >=85umol/L, but direct bilirubin accounts for more than 20% of total bilirubin; 3. Gestational age >= 28 weeks, birth weight >= 1000g; 4. Sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. There was a history of severe hypoxia at birth, and the 5-minute Apgar score was less than 5; 2. According to clinical manifestations, laboratory tests, etc., diagnosed with allergic diseases, inflammatory bowel diseases, and infectious diseases; 3. Other serious congenital malformations and immunodeficiencies; 4. It is impossible to complete the sampling before the gold standard diagnosis; 5. Give up further diagnosis and treatment, unable to obtain a definite diagnosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MMP-7;Ultrasound;sensitivity, specificity, accuracy; | — |
Countries
China
Contacts
Public ContactZheng Shan
Pediatric Hospital Affiliated to Fudan University
Outcome results
None listed