nonalcoholic fatty liver disease (NAFLD)
Conditions
Interventions
obese patients with nonalcoholic fatty liver disease:Nil
obese patients with normal liver:Nil
non-obese patients with nonalcoholic fatty liver disease:Nil
non-obese patients with normal liver:Nil
Sponsors
Shanghai Putuo District Center Hospital
Eligibility
Sex/Gender
All
Age
16 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 16-75 years, gender is not limited; 2. Weekly alcohol intake: no more than 210g for men and no more than 70g for women; 3. There are imaging changes of fatty liver in B-ultrasound or CT examination; 4. Exclude viral hepatitis, drug-induced liver disease, autoimmune liver disease and other autoimmune diseases, thyroid disease and other conditions that lead to fatty liver; 5. No history of major gastrointestinal surgery, such as subtotal gastrectomy and gastrointestinal anastomosis, radical colonectomy, small bowel resection, etc., except appendectomy, peptic ulcer perforation repair, etc.; 6. No serious heart, lung, brain, kidney disease and malignant tumor; 7. Women who are pregnant or who are willing to become pregnant in the near future are excluded.
Exclusion criteria
Exclusion criteria: 1. Combined with extrahepatic fibrotic diseases, including systemic lupus erythematosus, rheumatic diseases, renal failure, chronic obstructive pulmonary disease, tumor diseases, diabetes, hypertension, coronary heart disease, etc.; 2. Patients with alcoholic liver disease, cholestatic liver disease, hereditary metabolic liver disease and advanced liver cirrhosis with liver tumor were excluded; 3. Those who are currently or have received anti-hepatic fibrosis therapy or anti-viral therapy in the past, and those who have used enzyme-lowering drugs; 4. With jaundice, ALT and/or AST exceeds the upper limit of normal by 2 times or more; 5. Patients with incomplete clinical data related to this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood routine;hepatic function;renal function;blood lipid level;blood glucose;glycosylated hemoglobin;tumor marker;thyroid function;microelement;coagulation function;immunologic function;interleukin;indicators of hepatic fibrosis; | — |
Countries
China
Contacts
Public ContactCao Qin
Shanghai Putuo District Center Hospital
Outcome results
None listed