gout
Conditions
Interventions
case series:none
Sponsors
Shandong Provincial Clinical Research Center for Immune Diseases and Gout
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 80 years, no gender limit; 2. After a 2-week washout period, meet the diagnostic criteria for primary gout, serum uric acid >= 7.0 mg/dL (416 µmol/L); 3. eGFR >= 60ml/min/1.73m^2; 4. There is no acute gouty arthritis within 2 weeks before enrollment and within 2 weeks of the washout period; 5. Voluntarily participate and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Those who are allergic to all the drugs in this test or their ingredients, or those who have existing allergies, or those who have hypersensitivity constitution; 2. Patients with active liver disease or cirrhosis, or with abnormal liver function, whose serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) exceed 1.5 times the upper limit of the normal range; 3. Patients with active peptic ulcer; 4. Thyroid dysfunction; 5. Serum creatinine (Cr) exceeds the upper limit of the reference range; 6. Patients with severe heart disease, such as: decompensated heart failure (NYHA stage III and IV); unstable angina pectoris; history of myocardial infarction within the past 12 months, etc.; 7. Patients with xanthineuria; 8. Rheumatoid arthritis and other causes of joint disease that need to be treated; 9. Currently using azathioprine, 6-mercaptopurine, cyclosporine, cyclophosphamide, pyrazinamide, sulfamethoxazole, trimethoprim, theophylline, thiazide diuretics, aspirin (more than 325mg/day) or other salicylic acid drugs, losartan, intravenous colchicine; 10. Patients with secondary hyperuricemia caused by blood disease, kidney disease or tumor radiotherapy and chemotherapy; 11. Brain disease, abnormal judgment ability; mental illness unable to cooperate; 12. Alcohol or drug addicts; 13. Those who are pregnant, breastfeeding or intending to become pregnant, and women of childbearing age who do not use effective contraceptive measures (referring to intrauterine devices, oral contraceptives and obstructive measures); 14. Those who have participated in other clinical trials within three months before the screening of this trial; 15. Malignant tumor, active tuberculosis; 16. Complicated with other diseases, and the researchers believe that it will affect the evaluation of efficacy or poor compliance; 17. Those taking glucocorticoid drugs; 18. White blood cell count <4.0x10^9/L, or platelets <100x10^9/L, or hemoglobin <90g/L; 19. For any other reason, the investigator thinks it is not suitable to participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency of gout attacks;Range of motion of joints;Ultrasound signs of joints in patients with gout;Dual-source CT data; | — |
Countries
China
Contacts
Public ContactHan Lin
Affiliated Hospital of Qingdao University
Outcome results
None listed