Traumatic brain injury
Conditions
Interventions
Group 2:Placebo
Group 1:Perampanel treatment
Sponsors
The 904th Hospital of PLA
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18-65 years, male or non-pregnant female; 2. A clear history of the first and acute craniocerebral trauma, and the head CT scan is a traumatic brain injury; 3. Before the start of the study, the patients or their families signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. There are contraindications to the use of perampanel; 2. There are serious primary diseases such as heart, liver, kidney, etc.; 3. Accompanied by severe multiple injuries; 4. Pregnancy and lactation; 5. Unable to cooperate with the test procedure due to mental illness; 6. Participated in other clinical trials within three months; 7. The researcher believes that it is not suitable to participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glasgow Prognostic Score;Glasgow Coma Index;Cognitive function assessment;Activities of Daily Living Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| 30-day mortality;The incidence of epilepsy;Incidence of complications;Cerebral blood flow;Intracranial pressure; | — |
Countries
China
Contacts
Public ContactYang Likun
The 904th Hospital of PLA
Outcome results
None listed