Hepatitis B
Conditions
Interventions
HBeAg + group vs. HBeAg - group:None
Sponsors
Dongzhimen Hospital, Beijing University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. There is evidence that the diagnosis meets the diagnostic criteria of HBeAg negative and positive chronic hepatitis B, and those who routinely receive nucleoside (acid) analog antiviral therapy (entecavir); 2. Aged between 18-65 years; 3. Syndrome differentiation is a compound syndrome of ''liver stagnation and spleen deficiency, liver and gallbladder damp-heat''; 4. Voluntarily signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Serological test confirmed chronic hepatitis caused by hepatitis virus superinfection, non-viral infection (such as alcoholic liver disease), or cryptogenic hepatitis; 2. Patients with liver failure, liver cirrhosis (fibrosis S4 and above), hepatic encephalopathy, water-electrolyte and acid-base balance disorders, gastrointestinal bleeding, infection and other serious complications of chronic hepatitis B; 3. Those with a confirmed tumor, or a history of malignant tumor, or a progressive increase in tumor markers; 4. Patients with primary and/or secondary cardiovascular and cerebrovascular, lung, kidney, endocrine, digestive system, nervous and blood system diseases; 5. Those who have participated in or are participating in other clinical trials within one month; 6. Patients with mental disorders who cannot express their own feelings; 7. Women who plan to become pregnant and men who plan to conceive; 8. There are other situations that are not suitable for inclusion in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TCM syndrome scale;HBV core-associated antigen;HBV surface large protein;HBV pregenomic RNA; | — |
Countries
China
Contacts
Public ContactYe Yong'an
Outcome results
None listed