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Functional verification of intestinal barrier damage after Cth mediates intercellular repair through Erk1/2 pathway

Cth mediates postmortem repair of intestinal barrier through Erk1/2 pathway

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200055390
Enrollment
Unknown
Registered
2022-01-08
Start date
2022-02-01
Completion date
Unknown
Last updated
2023-01-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intestinal barrier

Interventions

case series:None

Sponsors

The Second Affiliated Hospital of Kunming Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Patients with colorectal cancer who need to undergo ileal preventive stoma, including patients with ultra-low rectal cancer who need preventive stoma and obstructive colon cancer preventive stoma; 2. Aged 18-70 years; 3. Able to communicate effectively; 4. Consciousness; 5. Informed consent to join this study.

Exclusion criteria

Exclusion criteria: 1. Pregnancy; 2. Cognitive dysfunction; 3. Patients transferred to ICU from other hospitals; 4. Patients with infectious complications on admission.

Design outcomes

Primary

MeasureTime frame
efferocytosis level;Cth, ERK1/2;—

Secondary

MeasureTime frame
intestinal barrier markers such as D-lactate and I-FABP;—

Countries

China

Contacts

Public ContactSun Dali

The Second Affiliated Hospital of Kunming Medical University

destinyky@163.com+86 13577047806

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026