hand-foot skin reaction (HFSR)
Conditions
Interventions
Experimental group:Recombinant human epidermal growth factor gel combined with urea ointment
Sponsors
Zhongshan Traditional Chinese Medicine Hospital Affiliated to Guangzhou University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged above 18 years, no gender limit; 2. Cancer patients taking anticancer drugs and with HFS/HFSR grade II or higher, and the expected treatment time of anticancer drugs is >=6 weeks (42 days); 3. Expected survival time > 6 months; 4. If HFS/HFSR was being treated with various modalities prior to enrollment, it was required to be ineffective for the treatment used. And the drug for HFS/HFSR should be discontinued for >=1 week before randomization; 5. If patients have used drugs to prevent HFS/HFSR before enrollment, but the preventive effect is not good, they can be enrolled after the occurrence of 2nd degree HFS/HFSR, but the preventive drugs need to be stopped for >=1 week. Or if the patient requests to continue to use the original prophylactic drug, the prophylactic drug is required for external use, and the original prophylactic regimen needs to be adhered to throughout the observation period of the trial; 6. ECOG score <= 2; 7. No history of serious heart, lung, liver, kidney and other important organ diseases; 8. Sign the informed consent; 9. Good patient compliance.
Exclusion criteria
Exclusion criteria: 1. Those with preexisting nervous system diseases; 2. Diabetes complicated with nervous system diseases; 3. Patients who are receiving other non-targeted drug therapy that may cause hand-foot syndrome; 4. Poor compliance; 5. Uncontrolled infections and metabolic diseases; 6. Pregnant or mentally ill patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ratio of HFS/HFSR recovery to 1 degree and ratio of recovery to 0 degree; | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement score of common symptoms of tumor;Improvement in quality of life score; | — |
Countries
China
Contacts
Public ContactMeng Jincheng
Zhongshan Traditional Chinese Medicine Hospital Affiliated to Guangzhou University of Chinese Medicine
Outcome results
None listed