Application of PAOO in closing space caused by mandibular first molar loss with insufficient alveolar bone

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200055363

Enrollment

Unknown

Registered

2022-01-08

Start date

2022-01-31

Completion date

Unknown

Last updated

2023-01-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

mandibular first molar loss with insufficient alveolar bone

Interventions

Experimental group:PAOO

Control group:No PAOO

Eligibility

Sex/Gender

All

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. Good general health and oral hygiene; 2. Permanent dentition, aged 18-45 years; 3. Diagnosed with malocclusion, requiring orthodontic treatment, closing the edentulous space of the mandibular first molar, and the alveolar bone shrinking at grade III or IV (Cawhood & Howell classification criteria).

Exclusion criteria

Exclusion criteria: 1. The third molar is missing or cannot be preserved; 2. Other systemic diseases such as bleeding disorders or diabetes; 3. Long-term use of drugs that affect bone metabolism and lead to gingival hyperplasia; 4. Active periodontal disease; 5. Pregnant or lactating patients.

Design outcomes

Primary

Measure	Time frame
Tooth movement speed;Alveolar bone mass;Gingival index;	—

Countries

China

Contacts

Public ContactZhao Qing

West China Hospital of Stomatology, Sichuan University

fanfan_qing@163.com+86 13880912310

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026