Acute Respiratory Distress Syndromn( ARDS)
Conditions
Interventions
control group:The tidal volume is 4-8ml/kg, the plateau pressure is less than 30cmH2O, and the positive end-expiratory pressure is set according to the mechanical ventilation parameter comparison tabl
transpulmonary pressure group:The ventilator parameters were adjusted to target end-inspiratory transpulmonary pressure (Ptp-i) <25cmH2O and end-expiratory transpulmonary pressure (Ptp-e) 0-5cmH2O.
driving pressure group:Drive pressure <16cmH2O Adjust ventilator parameters.
transpulmonary pressure+driving pressure group:At the same time, ensure that the end-inspiratory transpulmonary pressure (Ptp-i) <25cmH2O, the end-expiratory transpulmonary pressure (Ptp-e) 0-5cmH2O a
Sponsors
The Third Hospital of Hebei Medicial University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Must comply with the 2010 ARDS Berlin definition; 2. Need to receive invasive mechanical ventilation, aged 18-70 years.
Exclusion criteria
Exclusion criteria: Acute myocardial infarction, acute renal failure, pregnant patients, AECOPD, pulmonary fibrosis, definite valvular heart disease, and heart failure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 7-day mortality;28-day survival rate;ICU mortality;length of hospital stay;length of lCU stay;mechanical ventilation days;APACHE II score;SOFA score;lung compliance;resistance;peak airway pressure;platform pressure;extravascular lung water;lung permeability index;chest CT lung injury score;oxygen index;arteriovenous partial pressure of oxygen;arterial blood pressure;central venous pressure;heart rate;perfusion index;intrathoracic blood volume;cardiac output;systemic vascular resistance;ejection fraction;aortic velocity;left ventricular end-diastoilc volume;left ventricular end-systoilc volume;inferior vena cava width;creatinine;inferior vena cava diameter with respiratory variability;cystain C;neutrophil gelatinase-associated lipocalin assay;KDIGO classification;vascular permeability-related factor; | — |
Countries
China
Contacts
Public ContactFang Mingxing
The Third Hospital of Hebei Medicial University
Outcome results
None listed