Knee Osteoarthritis
Conditions
Interventions
Group 1:Intra-articular injection of platelet-rich plasma
Group 2:Intraarticular injection of platelet-rich plasma combined with ozone
Sponsors
General Hospital of Western Theater Command
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Knee pain and dysfunction; 2. Physical examination and imaging examination confirm the diagnosis of knee osteoarthritis; 3. K-L grading of knee osteoarthritis grades 1-3; 4. Patients without cognitive impairment who voluntarily participate in this study; 5. Aged 40-80 years.
Exclusion criteria
Exclusion criteria: 1. Skin disease around the injection area, skin ulceration around the puncture, or patients with obvious joint swelling and fluid accumulation caused by other diseases cannot be excluded; 2. Patients with abnormal coagulation function or undergoing anticoagulation therapy; 3. Serious systemic diseases have not been effectively controlled; 4. Those who have central nervous system diseases, mental diseases, and cannot communicate normally; 5. Contraindications for autologous blood transfusion such as immunosuppression, tumors or other serious diseases; 6. The researcher believes that it is not suitable to participate in the experiment or other situations that cannot cooperate with the research for any reason.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index;Imaging changes (X-ray, MRI, ultrasound, CT); | — |
Secondary
| Measure | Time frame |
|---|---|
| General information of patients (age, sex, body mass index, occupation);Vital signs during treatment;Adverse reactions;Treatment satisfaction score;Healthy Quality of Life Questionnaire SF-8;SAS Anxiety Self-rating Scale; | — |
Countries
China
Contacts
Public ContactWu Wei
General Hospital of Western Theater Command
Outcome results
None listed