Single-cell RNA sequencing to analyze the mechanism of immune cells involved in the pathogenesis of type I diabetes

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2200055344

Enrollment

Unknown

Registered

2022-01-07

Start date

2022-01-01

Completion date

Unknown

Last updated

2023-01-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

type 1 diabetes

Interventions

case series:None

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. The age of onset is less than 15 years old and the newly diagnosed diabetes is less than 100 days old. At the time of diagnosis, the weight was in the lower quartile of the same age group or the BMI was in the lower 1/2 quartile of the same age group; 2. Positive type 1 diabetes-related antibodies (GAD65, IAA, ICA or ZnT8) or positive insulin autoantibodies (IA-2 and IA-2B) within 10 days of starting insulin therapy; 3. The patient has experienced diabetic ketosis or DKA; 4. Fasting C-peptide is less than 200pmol/L; 5. No infectious diseases, no other metabolic diseases, no other immune diseases; 6. Patients with secondary diabetes, heart failure, malignant tumor, cerebrovascular accident and mental illness were excluded.

Exclusion criteria

Exclusion criteria: None

Design outcomes

Primary

Measure	Time frame
CD4 CD8 cell;	—

Countries

China

Contacts

Public ContactLiang Liyang

liangliy@mail.sysu.edu.cn+86 19927412576

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026