Strategies and mechanisms of rapid relief of suicidal ideation in patients with depression by neuro-directional navigational transcranial magnetic stimulation

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200055320

Enrollment

Unknown

Registered

2022-01-06

Start date

2021-12-01

Completion date

Unknown

Last updated

2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Treatment resistant depression

Interventions

iTBS group:Use of transcranial magnetic stimulation (TMS) iTBS in the treatment of patients with depression

cTBS group:Use of transcranial magnetic stimulation (TMS) cTBS in the treatment of patients with depression

Healthy controls:Healthy subjects with matched gender, age and education level were selected as the control group, and the exclusion criteria were the same as the depression group. General demographic

Eligibility

Sex/Gender

All

Age

13 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. This episode meets the diagnostic criteria of DSM-5 major depression, is not accompanied by psychotic symptoms, and is ineffective after at least one antidepressant treatment for one month; 2. The total score of the 24-item Hamilton Depression Scale (HAMD-24) is >=20, the third item of HAMD-24 is >= 3 and the total score of the Baker Suicidal Ideation Scale is >=12; 3. Han nationality, right-handed; 4. Junior high school education level or above; 5. Aged between 13-45 years.

Exclusion criteria

Exclusion criteria: 1. Epilepsy patients, patients with metal objects in the body and patients with acute cerebrovascular accident; 2. A history of alcohol or drug abuse or dependence; 3. Patients with organic mental disorders and mental retardation; 4. Patients who received electroconvulsive shock without convulsions in the past or three months; 5. Patients with severe neurological, heart, liver and kidney, endocrine, blood system and other physical diseases or diseases that may interfere with the evaluation of the test.

Design outcomes

Primary

Measure	Time frame
Hamilton Depression Scale;Hamilton Anxiety Scale;Beck Scale of Suicidal Ideation;Sneth Hamilton Pleasure Scale;Columbia Suicide Severity Rating Scale;	—

Secondary

Measure	Time frame
Motivation and Energy Inventory;EEG;TMS-EEG;MRI;	—

Countries

China

Contacts

Public ContactLuan Honglin

Wenzhou Seventh People's Hospital

luanhonglin0314@163.com+86 137 7745 8752

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Apr 23, 2026