A randomized controlled study of Qingre Lishi decoction and antibiotics in the treatment of chronic endometritis

A multicenter randomized controlled study on the efficacy of traditional Chinese medicine and antibiotics in the treatment of chronic endometritis in women of reproductive age between 18 and 40 years old

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200055294

Enrollment

Unknown

Registered

2022-01-05

Start date

2022-01-01

Completion date

Unknown

Last updated

2023-01-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic endometritis (CE)

Interventions

Experimental group:Modification of Qingre Lishi Decoction

Control group:Antibiotics

Eligibility

Sex/Gender

Female

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1. Women of childbearing aged between 18 and 40 years; 2. CE was diagnosed by immunohistochemical detection of endometrial histopathological CD138; diagnostic criteria: >=1CD138 positive cells/10HPF; 3. The TCM syndrome type is qi deficiency and damp-heat type; 4. Voluntarily sign a written informed consent; 5. Histopathological diagnosis does not suggest endometrial hyperplasia or endometrial cancer; 6. Willing to accept repeat hysteroscopy and endometrial histopathological examination to evaluate CE outcome.

Exclusion criteria

Exclusion criteria: 1. Received estrogen and progesterone therapy within 1 month; 2. Received traditional Chinese medicine and antibiotic treatment within 1 month; 3. Modification and subtraction of traditional Chinese medicine ingredients and antibiotic allergy history of Qingre Lishi Decoction; 4. There are other medical indications that require antibiotic treatment before repeat hysteroscopy and endometrial histopathological examination; 5. Need to take estrogen and progesterone due to illness; 6. Pregnancy status and pregnancy-related diseases; 7. Random grouping will not be accepted.

Design outcomes

Primary

Measure	Time frame
Endometrial CD138 negative conversion rate;	—

Secondary

Measure	Time frame
Endometrial CD56 changes;Hysteroscopy microscopic features;	—

Countries

China

Contacts

Public ContactSong Dongmei

Fuxing Hospital Affiliated to Capital Medical University

echosdm@163.com+86 10 88062220

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026