Prevention and treatment of probiotics in patients with chronic periodontitis

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200055285

Enrollment

Unknown

Registered

2022-01-05

Start date

2022-01-04

Completion date

Unknown

Last updated

2023-01-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

periodontitis

Interventions

Probiotic ET-22 live bacteria group:Take three ET-22 live bacteria milk tablets daily for 6 weeks

Probiotic ET-22 dead bacteria group:Take three ET-22 dead bacteria milk tablets daily for 6 weeks

Control group:Take three milk tablets daily for 6 weeks

Probiotic A6+L9 live bacteria group:Take three A6+L9 live bacteria milk tablets daily for 6 weeks

Eligibility

Sex/Gender

All

Age

25 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Aged 25-60 years, no major diseases; 2. The probing pocket depth of more than 30% of the teeth is 2-5mm; 3. Clinical attachment level (clinical attachment level) 1-4mm.

Exclusion criteria

Exclusion criteria: 1. Received periodontitis treatment 3 months before the start of the experiment; 2. Receive antibacterial, anti-inflammatory treatment, and take antibiotics 3 months before the start of the experiment; 3. Major diseases (diabetes, autoimmune system); 4. Pregnant patients, smoking.

Design outcomes

Primary

Measure	Time frame
Probing depth;Clinical attachment loss;Bleeding on probing;Gingival index;	—

Countries

China

Contacts

Public ContactRen Fazheng

China Agricultural University

zhangming@th.btbu.edu.cn+86 13581769686

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026