None listed
Conditions
Interventions
Group 1:12ug/kg alfentanil
Group 2:6ug/kg alfentanil
Group 3:3ug/kg alfentanil
Sponsors
The Second Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Aged >= 65 years; 2. ASA grade II-III; NYHA grade II-III; 3. No history of allergy to anesthetics; 4. Agree to participate in this study and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Those who are intolerant to opioids and other drugs; 2. Patients with congenital heart disease, acute coronary syndrome, severe ventricular arrhythmia, atrial fibrillation, severe valvular regurgitation, and NYHA grade IV severe heart disease; 3. History of severe chronic obstructive pulmonary disease (COPD severity grade III or IV), severe or uncontrolled bronchial asthma, lung infection, bronchiectasis; 4. Those who are confirmed or suspected to have abused or used other narcotic sedatives and analgesics and long-term alcohol abuse patients; 5. Morbid obesity (body mass index > 30 kg/m^2), history of receiving anesthesia within the last 7 days, and known allergies to study drugs; 6. The attending doctor or the researcher believes that there are other circumstances that are not suitable for participating in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Activity of diaphragm; | — |
Secondary
| Measure | Time frame |
|---|---|
| Thickness of diaphragm;Change rate of the thickness of diaphragm;Inspiration time;Thickness of rectus abdominis;Thickness of lateral abdominal muscle;Blood pressure;Heart rate;Pulse oxygen saturation;Respiratory rate;Tidal volume;Thoracic impedance tomography;Inhomogeneity index;Ventilation center; | — |
Countries
China
Contacts
Public ContactHuang He
The Second Affiliated Hospital of Chongqing Medical University
Outcome results
None listed