severe mycoplasma pneumoniae pneumonia
Conditions
Interventions
Test group:The experimental group used cyclic ester erythromycin combined with azithromycin to treat SMPP
control group:Treatment of SMPP with azithromycin
Sponsors
Maternity and Child Health Hospital of Hubei Province
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Based on the diagnosis of MPP, any 2 of the first 3 and (or) any 1 of the last 2 of the following criteria are used as the diagnostic criteria for SMPP: 1. Obvious shortness of breath or tachycardia (= 50 beats/minute, heart rate >= 150 beats/minute; 1-5 years old, breathing >= 40 beats/minute, heart rate >= 140 beats/minute; > 5 years old, breathing >= 30 beats/minute, heart rate >= 120 beats/minute), With or without a decrease in arterial blood pressure (systolic blood pressure = 38.5? or lung imaging does not improve or even progress), or the fever lasts for more than 10 days; 3. The chest imaging shows large patches of shadows , Occupying a lung segment or above the lung lobe, can involve single or multi-lobe lesions; 4. Pulmonary complications such as pleural effusion, atelectasis, necrotizing pneumonia/pulmonary abscess, etc.; 5. Severe hypoxemia (PaO2 < 60mmHg) or combined with serious damage to other functions (central nervous system infection, heart failure, myocarditis, gastrointestinal bleeding, obvious electrolyte/acid-base balance disorder, etc.).
Exclusion criteria
Exclusion criteria: 1.Infectious diseases of other systems (such as cardiovascular, nervous, urinary, digestive system, etc.), and pneumonia as co-infected; 2.Patients who are allergic or allergic to the drugs in this study; 3.Congenital immunodeficiency; 4.Recently Those who use other medications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CRP;LDH;ESR;HGF;TNF-a;IL-4;IL-6;IL-10; | — |
Countries
China
Contacts
Public ContactYue Jing
Maternity and Child Health Hospital of Hubei Province
Outcome results
None listed