schizophrenia, depressive disorder
Conditions
Interventions
Oxygen uptake group:Oxygen for 2 hours after each MECT, 3L/min
Non-oxygen group:Normal measure
Sponsors
The Second Affiliated Hospital of Xinxiang Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1.MECT group: (1) Meet the diagnostic criteria for the corresponding disease in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V); (2) Aged 18-45 years, Han nationality, right-handed; (3) Meet the indications for MECT and have no contraindications; (4) No prior electroconvulsive therapy. 2. Drug group (MED group): (1) Meet the corresponding diagnostic criteria in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V); (2) Aged 18-45 years, Han nationality, right-handed; (3) Have not received electroconvulsive therapy. 3. Healthy control group (HC group): (1) After SID-V screening, there is no mental illness in line with DSM-V axis I. No psychiatric disorder or inherited neurological disorder in first-degree relatives; (2) Aged 18-45 years, Han nationality, right-handed; (3) Subjects voluntarily participated in this trial and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1.MECT group: (1) Combined with other mental disorders or drug or alcohol dependence; (2) Suffering from serious physical diseases such as heart, liver and renal insufficiency; (3) Pregnant or lactating subjects; (4) History of major head trauma (loss of consciousness, time > 5 min), neurological disease; (5) There are contraindications for magnetic resonance examination (with metal implants in the body, claustrophobia, etc.) and EEG contraindications (head trauma and unhealed incisions after surgery, etc.); (6) Subjects who are participating in other clinical trials. 2. Drug group (MED group): (1) Combined with other mental disorders or drug or alcohol dependence; (2) Suffering from serious physical diseases such as heart, liver and renal insufficiency; (3) Pregnant or lactating subjects; (4) History of major head trauma (loss of consciousness, time > 5 min), neurological disease; (5) There are contraindications for magnetic resonance examination (with metal implants in the body, claustrophobia, etc.) and EEG contraindications (head trauma and unhealed incisions after surgery, etc.); (6) Subjects who are participating in other clinical trials. 3. Healthy control group (HC group): (1) History of alcohol and/or drug abuse and dependence (except nicotine dependence); (2) History of head trauma (loss of consciousness, time > 5 min), neurological disease; (3) Suffering from serious physical diseases such as heart, liver and renal insufficiency and poorly controlled diabetes; (4) Subjects who are pregnant or breastfeeding; (5) There are contraindications for magnetic resonance examination (with metal implants in the body, claustrophobia, etc.) and EEG contraindications (head trauma and unhealed incisions after surgery, etc.); (6) Subjects who are participating in other clinical trials that may affect the results of this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| magnetic resonance imaging measure index;EEG;biochemical indicators of blood metabolism;cognitive function;assessment of clinical symptoms;social psychology assessment; | — |
Countries
China
Contacts
Public ContactZhang Hongxing
The Second Affiliated Hospital of Xinxiang Medical University
Outcome results
None listed