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A multicenter randomized controlled study of hydrochlorothiazide on the morbidity of hypertension in prehypertensive population with high salt threshold

Evaluation of the effectiveness of hydrochlorothiazide in reducing the morbidity of hypertension in prehypertension patients with high salt threshold: a multicenter randomized controlled clinical trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200055240
Enrollment
Unknown
Registered
2022-01-04
Start date
2021-12-27
Completion date
Unknown
Last updated
2023-01-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prehypertension

Interventions

experimental group:Hydrochlorothiazide
control group:Placebo

Sponsors

Daping Hospital of Third Military Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
45 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. The resident population of Chongqing municipality; 2. Aged >= 45 years; 3. Ambulatory blood pressure measurement is consistent with prehypertension (120-139/80-89mmHg); 4. Undiagnosed primary and/or secondary hypertension; 5. Not taking antihypertensive drugs; 6. Salt threshold screening for those who meet the high salt threshold; 7. Informed consent has been obtained and signed.

Exclusion criteria

Exclusion criteria: 1. There may be primary and/or secondary hypertension; 2. Patients with severe heart, liver, kidney, and endocrine system diseases, and the expected survival period is less than 3 years; 3. Those who have a history of allergy to this drug or its ingredients after taking it; 4. Participating in other clinical investigators; 5. Those with poor compliance or the researchers believe that they are not suitable for clinical trials for other reasons; 6. Those who suffer from factors such as disability, activity disorder, intellectual disability, etc., which may prevent normal participation in research and follow-up; 7. Patients who are judged by the doctor to be unable to participate in the study.

Design outcomes

Primary

MeasureTime frame
Morbidity of hypertension;

Secondary

MeasureTime frame
Blood pressure;Atherosclerotic cardiovascular disease events;

Countries

China

Contacts

Public ContactZeng Chunyu

Daping Hospital of Third Military Medical University

chunyuzeng01@163.com+86 13983624369

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026