knee osteoarthritis
Conditions
Interventions
liver and kidney deficiency syndrome group:None
phlegm and blood stasis syndrome group:None
normal control group:None
Sponsors
Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria for Knee Osteoarthritis of Liver and Kidney Deficiency Syndrome and Phlegm and Blood Stasis Syndrome: (1) Aged 20-80 years, in line with the diagnostic criteria of Western medicine. (2) In line with the TCM syndrome diagnosis criteria, it belongs to liver-kidney deficiency syndrome and phlegm and blood stasis syndrome. (3) Patients who are willing to participate in the survey and have good compliance. (4) Voluntarily signed the informed consent. 2. Inclusion criteria for normal control group: (1) Aged 20-80 years. (2) Patients who are willing to participate in the survey and have good compliance. (3) Does not meet the diagnostic criteria for knee osteoarthritis disease. (4) Voluntarily signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Complications affecting the joints, such as psoriasis, syphilitic neuropathy, brown yellow disease, metabolic bone disease, etc.; 2. Combined with rheumatoid arthritis and ankylosing spondylitis; 3. Those who are disabled or incapacitated in the late stage; 4. Pregnant or lactating patients; 5. The mentally ill.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| human B-lymphocyte chemokine 1;eosinophil chemotactic protein;recombinant human eotaxin-2;granulocyte colony stimulating factor;granulocyte-macrophage colony stimulating factor;eosinophil chemoattractant protein CCL1 antibody;intercellular adhesion molecule 1;interferon gamma;IL-1 alpha (IL-1 F1);IL-1 beta (IL-1 F2);IL-1 ra (IL-1 F3);IL-2;IL-4;IL-5;IL-6;IL-6 R;IL-7;IL-8(CXCL8);IL-10;IL-11;IL-12 p40;IL-12 p70;IL-13;IL-15;IL-16;IL-17A;monocyte chemoattractant protein-1;recombinant human macrophage colony stimulating factor;chemokine CXC ligand 9;MIP-1;recombinant human macrophage inflammatory factor-1a/chemokine;MIP-1 beta (CCL4);MIP-1 delta;PDGF-BB;RANTES(CCL5);TIMP-1;TIMP-2;TNF alpha;TNF beta (TNFSF1B);TNF RI (TNFRSF1A);TNF RII(TNFRSF1B);TCM syndrome score scale;radiographic image;metabonomics;proteomics;transcriptomics;protein microarray;histological detection;pathological examination;enzyme-linked immunosorbent assay;signaling pathway indicator;cytokine index;related indexes of disease and syndrome cell model;Knee Osteoarthritis Disease Scale;general patient information;routine examination of patients in hospital;serum, blood cells, articular fluid, urine, tongue coating, discarded tissues after surgery and disease cell model related indicators;multiple omics analysis; | — |
Countries
China
Contacts
Public ContactYe Chao
Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine
Outcome results
None listed