FindTrial
Sign In

Effect of lung protective ventilation on perioperative lung injury in patients undergoing spinal surgery

Effect of lung protective ventilation on perioperative lung injury in patients undergoing spinal surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200055229
Enrollment
Unknown
Registered
2022-01-03
Start date
2019-06-01
Completion date
Unknown
Last updated
2023-01-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ventilator-associated lung injury

Interventions

Control group:VT 10ml/kg (PBW), f 12 times/min, PEEP=0 cm H2O
Experimental group:VT 6ml/kg (PBW), f 15 times/min, I:E=1:2, PEEP=4 cm H2O, lung recruitment

Sponsors

Third Hospital of Hebei Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. ASA classification II to III; 2. There is no gender limit, and aged over 18 years; 3. BMI: 18.5-23.9kg/m^2.

Exclusion criteria

Exclusion criteria: 1. Suffering from autoimmune disease; 2. Preoperative combined respiratory disease and serious infection; 3. Preoperative bed rest time > 1 month; 4. Apply a ventilator before surgery.

Design outcomes

Primary

MeasureTime frame
Clara cell secreted protein 16;Soluble receptor for advanced glycation end products;IL-8;Arterial oxygen partial pressure;Arterial carbon dioxide partial pressure;Pulmonary complications;—

Secondary

MeasureTime frame
Peak airway pressure;—

Countries

China

Contacts

Public ContactWang Xiuli

Third Hospital of Hebei Medical University

wangxl301@aliyun.com+86 18533112928

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026