breast cancer
Conditions
Interventions
C group:sufentanil-remifentanil
N group:opioid-free general anesthesia + erector spinae nerve block
Sponsors
Affiliated Hospital of Yangzhou University
Eligibility
Sex/Gender
Female
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective modified radical mastectomy for unilateral breast cancer; 2. Aged 20-65 years; 3. Body mass index (BMI) 18-30kg/m^2; 4. American Society of Anesthesiologists (ASA) grades I-II; 5. Those who agree to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with preoperative acute and chronic pain; 2. Patients with serious heart, brain, lung, liver, kidney and other major organ diseases; 3. Those who are allergic to dexmedetomidine, lidocaine, ropivacaine and other drugs used in the test; 4. Patients with severe bradycardia (preoperative heart rate <50bpm) or those with abnormal cardiac conduction and rhythm; 5. Patients with abnormal coagulation function; patients with moderate or more anemia (hemoglobin <90g/L); 6. Pregnant or lactating patients, patients with motion sickness; 7. Long-term use of sedatives, analgesics, long-term alcoholism or drug abuse; 8. There are contraindications to nerve block; 9. Those with a history of mental illness, language and communication impairment, hearing impairment, and inability to understand the test content.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Perioperative hemodynamics;Visual analogue scale pain score;Postoperative adverse reactions;Postoperative usage of analgesics;Post-operative chronic pain; | — |
Secondary
| Measure | Time frame |
|---|---|
| Extubation time;PACU stay time;15-item quality of recovery rating scale;Self-rating depression scale;Perioperative amount of anesthetics;Ramsay sedation score;Length of hospital stay and total cost;Stress hormone level; | — |
Countries
China
Contacts
Public ContactShen Tongtao
Affiliated Hospital of Yangzhou University
Outcome results
None listed