schizophrenia
Conditions
Interventions
Active-tDCS group:Active-tDCS
Sham-tDCS group:Sham-tDCS
Sponsors
Shanghai Mental Health Center
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Inpatients with schizophrenia in Shanghai Mental Health Center; 2. Meet the diagnostic criteria of DSM-5 for schizophrenia; 3. Aged between 18 and 55; 4. After 6 weeks of treatment with two or more antipsychotic drugs (400-600 mg/day equivalent dose of CPZ), the symptoms of auditory hallucinations are still not relieved (Audio hallucination rating scale (AHRS) total score> 18 points); 5. Patients and their families signed a written informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with organic brain diseases, patients with psychoactive substances or alcohol dependence, patients with epilepsy and intellectual disabilities; 2. Suffering from severe or unstable physical diseases, or abnormal laboratory tests and judged to be clinically significant, the researchers believe that it affects the safety of the patients; 3. Contraindications for tDCS: intracranial metal foreign body, cochlear implant, intracranial hypertension; 4. Those who have received ECT within 6 months; 5. Pregnant, lactating patients, women of childbearing age with positive urine HCG test results during the screening period; 6. Patients with obvious negative impulses and disordered behaviors who cannot cooperate with the examination; 7. The investigator believes that there are other circumstances that are not suitable for participating in the clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Auditory Hallucination Rating Scale (AHRS) Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Calgary Depression Scale for Schizophrenia (CDSS) Score;CogState Cognitive Function Assessment;UPSA-B Social Function Assessment;Multimodal magnetic resonance imaging;Inflammatory cytokines; | — |
Countries
China
Contacts
Public ContactZhang Yi
Shanghai Mental Health Center
Outcome results
None listed