postoperative sleep disturbance
Conditions
Interventions
Experimental group:Sufentanil 2 µg/kg + ketochromate tromethamine 90 mg + S-ketamine 50 mg + tropisetron 30 mg + 0.9 % sodium chloride solution, volume 120 ml
Control group:Sufentanil 2 µg/kg + ketochromate tromethamine 90 mg + tropisetron 30 mg + 0.9 % sodium chloride solution, volume 120 ml
Sponsors
Peking University Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged >=18 years and <65 years; 2. BMI between 18-30 kg/m^2; 3. ASA classification II-III; 4. No serious liver, kidney, heart, brain, lung and other important organ diseases before surgery; 5. Patients who are expected to be hospitalized for 4 days or more. 6. The operation can be completed before 20pm.
Exclusion criteria
Exclusion criteria: 1. Refuse to participate in this research; 2. Patients with tumor recurrence; 3. Combined with primary malignant tumors in other parts, and received multiple operations during a single surgical operation; 4. Patients receiving long-term psychotropic drug therapy, hormone therapy and long-term use of opioids or non-steroidal anti-inflammatory analgesics; 5. Preoperative diagnosis of schizophrenia, dementia, Alzheimer's disease, delirium, unable to communicate due to language barriers or end-stage diseases; 6. Long-term use of sleeping pills, history of obstructive sleep apnea syndrome, poorly controlled or untreated hypertension (arterial hypertension, resting systolic/diastolic blood pressure exceeds 180/100 mmHg); 7. Severe heart block and (or) severe ventricular insufficiency, severe liver dysfunction (Child-Pugh class C); 8. Severe renal dysfunction (those who received renal replacement therapy before surgery); 9. Patients who are allergic to S-ketamine or sufentanil active ingredients or excipients; 10. Other researchers think that it is not suitable for inclusion (specific reasons should be indicated).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative sleep quality;serum cytokines; | — |
Secondary
| Measure | Time frame |
|---|---|
| time to first postoperative exhaust;dosage of analgesics within 72 hours after the operation;visual analogue scale;adverse reaction; | — |
Countries
China
Contacts
Public ContactTan Hongyu
Peking University Cancer Hospital
Outcome results
None listed