Coronary atherosclerotic heart disease
Conditions
Interventions
Elective percutaneous coronary intervention (PCI) standard care group:none
Sponsors
Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years; 2. The two groups of patients with MI were all patients with acute anterior wall ST-segment elevation myocardial infarction in our hospital. The PCI treatment was completed within 12 hours of the onset. The proximal segment of the anterior descending artery is defined as the end of the left main trunk to the origin of the first diagonal branch; 3. The two groups of patients with SPCI were patients with a single proximal anterior descending artery disease who underwent elective PCI opening. The proximal segment of the anterior descending artery is defined as the end of the left main trunk to the origin of the first diagonal branch artery, and the proximal segment of a single anterior descending artery lesion is defined as the proximal segment of the anterior descending artery with stenosis >=70% and the degree of stenosis of the rest of the coronary arteries <=50%; 4. All patients were successfully opened for anterior descending artery lesions during the operation, and the success criteria were: residual stenosis <20%, no tear, thrombosis or signs of embolism in distal vessels; 5. The patients gave informed consent and signed the informed consent form. Able to attend outpatient follow-up visits.
Exclusion criteria
Exclusion criteria: 1. The angiography of the myocardial infarction group showed that the anterior descending artery was recanalized, and the TIMI blood flow was grade 3; 2. Have received thrombolytic therapy before PCI; 3. No previous history of cardiac insufficiency caused by any cause; 4. No history of structural heart disease, including valvular heart disease, congenital heart disease, pulmonary heart disease, cardiomyopathy, etc.; 5. No previous myocardial infarction; 6. Mental patients; 7. Participated in other clinical trials (just completed or still in progress within the past 2 months); 8. Pregnant or breastfeeding or planning to become pregnant; 9. The researcher judges that the compliance is not good and cannot strictly implement the plan; 10. Any other circumstances that the investigator considers inappropriate to participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Perfusion defect area;Perfusion defect score; | — |
Secondary
| Measure | Time frame |
|---|---|
| New York Heart Association Functional Class;Left ventricular end diastolic diameter;Left ventricular ejection fraction;Status of arrhythmia;N-terminal natriuretic peptide precursor;Malondialdehyde;NO;Nitric oxide synthase;Copper zinc superoxide dismutase;Manganese superoxide dismutase;IL-6;TNF-a;Whole blood viscosity;Major adverse cardiovascular events; | — |
Countries
China
Contacts
Public ContactYang Ying
Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University
Outcome results
None listed