Early gastric cancers
Conditions
Interventions
Group A:ESD preoperative eradication
Group B:Post-ESD eradication
Sponsors
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Those who have been diagnosed as early gastric cancer (EGC) and high-grade intraepithelial neoplasia (HGN) by endoscopic diagnosis or/and biopsy and will receive endoscopic treatment (ESD) in our hospital; 2. Patients with definite H. pylori infection, that is, positive for any of the following tests: breath test, rapid urease test, stool antigen, and histopathology showing H. pylori; 3. Those who signed informed consent and were able to accept outpatient follow-up.
Exclusion criteria
Exclusion criteria: 1. Those who have received H. pylori eradication therapy in the past 1 month; 2. Those who have undergone gastric surgery (partial resection) (those who have undergone gastric ESD are not excluded); 3. Those with poor general condition, or those with contraindications to endoscopy; 4. Those who are pregnant and breastfeeding; 5. Those who are allergic to eradication drugs.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Occurrence rate of gastritis-like epithelium;ESD complete removal rate;ESD curative resection rate;ESD unit operating time;Complications and incidence of simultaneous/metachronous cancer;Hp eradication rate;Hp 6 month recurrence rate (reburn);Hp 1-year recurrence rate (reinfection); | — |
Primary
| Measure | Time frame |
|---|---|
| Ratio of negative margins at ESD level;Ratio of negative at 5mm mark; | — |
Countries
China
Contacts
Public ContactWu Xi
Outcome results
None listed