Individualized and precise positioning of TMS based on fMRI motor task activation points in the treatment of post-stroke hemiplegia

fMRI-guided individual precise localization transcranial magnetic stimulation for patients with post-stroke hemiplegia

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200055157

Enrollment

Unknown

Registered

2022-01-02

Start date

2022-05-20

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemiplegia after stroke

Interventions

fMRI-rTMS group:repetitive transcranial magnetic stimulation

hotspot-rTMS group:repetitive transcranial magnetic stimulation

healthy control group:none

Eligibility

Sex/Gender

All

Age

30 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. The initial onset, non-lateral motor area stroke lesions, with a course of 2 weeks to 3 months; 2. Hemiplegia with unilateral hemisphere injury; 3. Brunnstrom classification (Brunnstrom, 1966)<=IV stage; 4. Agree to carry out rTMS treatment on the basis of conventional treatment, pass TMS safety screening, have no previous epilepsy and other neuropsychiatric diseases, and no other motor system diseases; 5. No contraindications to MRI scanning, no history of head trauma and severe heart disease; 6. Unconscious disturbance; 7. Can cooperate with the main test to complete the scale evaluation, MRI scan and TMS treatment; 8. Motor evoked potentials can be obtained in the contralateral and affected hemispheres; 9. Able to complete hands-on tasks, and obtain activation points in the lateral motor area of the unaffected hemisphere, and obtain the strongest functional connection between the lateral motor area of the affected hemisphere and the activation point of the unaffected hemisphere; 10. The head movement amplitude of all fMRI images is less than 2mm in translation and less than 2 degree in rotation; 11. Have not taken any drugs with muscle relaxation effect recently.

Exclusion criteria

Exclusion criteria: 1. There are more serious complications (including renal and hepatic insufficiency, myocardial infarction, heart failure, gastrointestinal bleeding, severe infection, mental disorder and dementia, epilepsy, bone and joint disease, etc.); 2. Those with claustrophobia; 3. A pacemaker is installed in the body; 4. Pregnant patients.

Design outcomes

Primary

Measure	Time frame
resting state functional connectivity;ALFF;Fugl-Meyer;	—

Countries

China

Contacts

Public ContactZang Yufeng

zangyf@hznu.edu.cn+86 18606517380

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026