Effect of preadministration of nalmefene on sufentanil-induced cough during general anesthesia in breast cancer patients

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200055139

Enrollment

Unknown

Registered

2022-01-01

Start date

2022-01-01

Completion date

Unknown

Last updated

2023-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Group LN:a single bolus of 0.1ug/kg nalmefene given before induction of general anesthesia

Group HN:a single bolus of 0.25ug/kg nalmefene given before induction of general anesthesia

Group C:a single bolus of saline given before induction of general anesthesia

Eligibility

Sex/Gender

Female

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Breast cancer patients who need elective surgery; 2. Aged 18-60 years; 3. ASA classification I-II; 4. BMI 18-24 kg/m^2.

Exclusion criteria

Exclusion criteria: 1. Patients with liver and kidney insufficiency in the past, accompanied by severe nervous system or cardiovascular system diseases; 2. Allergic to nalmefene and other anesthetics; 3. Chronic cough, smoking, upper respiratory tract infection or asthma within 2 weeks; 4. Long-term use of ACEI/ARB, bronchodilators, hormones or opioids; 5. Predict that there may be a difficult airway; 6. Preoperative intracranial pressure, intra-abdominal pressure or intraocular pressure increased.

Design outcomes

Primary

Measure	Time frame
Incidence of sufentanil-induced choking;	—

Secondary

Measure	Time frame
Hemodynamics;Postoperative pain intensity (NRS);Postoperative opioid-related adverse reactions (including: postoperative nausea and vomiting, chills, somnolence, headache);Time to extubation;Length of stay;Severity of sufentanil-induced cough;Time to first sufentanil-induced choking;	—

Countries

China

Contacts

Public ContactLi Yongchun

Sun Yat-Sen University Cancer Center

liyongch@sysucc.org.cn+86 13580448105

Outcome results