non-small cell lung cancer (NSCLC)
Conditions
Interventions
case series:None
Sponsors
The Second Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-75 years; 2. Advanced non-small cell lung cancer (IIIB-IV stage), pathological type limited to squamous cell carcinoma or adenocarcinoma (no EGFR/ALK/ros1 gene mutation); 3. General condition: ECOG score 0 or 1; 4. Receive first-line immune checkpoint inhibitor monotherapy or combination therapy; 5. Sustained benefit of immunotherapy, defined in this study as PFS >= 1 year (the efficacy evaluation is CR/PR/SD); 6. Tumor tissue samples are available at the time of enrollment, and at least 5-10 sections can be generated, and the pathology report indicates that the total tumor content is not less than 10%; 7. There is at least one measurable lesion (except for patients with CR after first-line treatment), which can be evaluated according to RECIST1.1 criteria; 8. Have self-awareness, be able to understand the research plan and voluntarily participate in this research, and can sign the informed consent; 9. Good compliance, able to cooperate with the collection of specimens from each node and provide corresponding clinical information.
Exclusion criteria
Exclusion criteria: 1. Serious primary diseases of the heart, liver, kidney, hematopoietic system, etc.; 2. Suffering from other malignant tumors within 3 years before the diagnosis of NSCLC; 3. Pregnant and lactating patients; 4. Active period of human immunodeficiency virus (HIV) infection; 5. Those with active systemic infection, pneumonia, tuberculosis, and pericarditis; 6. Patients who cannot understand the experimental content and cannot cooperate and those who refuse to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression-free survival;Lead time;Overall survival; | — |
Countries
China
Contacts
Public ContactWu Fang
The Second Xiangya Hospital of Central South University
Outcome results
None listed