Effect and mechanism of perioperative application of esmketamine on postoperative cognitive function in patients undergoing general anesthesia

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200055119

Enrollment

Unknown

Registered

2022-01-01

Start date

2022-01-03

Completion date

Unknown

Last updated

2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

control group:None

experimental group:Esketamine

Eligibility

Sex/Gender

All

Age

40 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Patients undergoing general anesthesia surgery; 2. Sign the informed consent; 3. Anesthesia grades I-III.

Exclusion criteria

Exclusion criteria: 1. Patients who have recently taken psychotropic drugs or sleeping pills; 2. Patients with important organ lesions and malignant tumors; 3. Patients who are allergic to this drug.

Design outcomes

Primary

Measure	Time frame
Simple Mental State Examination Scale Score;	—

Secondary

Measure	Time frame
Apoptosis level;Inflammatory response level;NMDA expression level;Oxidative stress level;	—

Countries

China

Contacts

Public ContactKong Mingjian

Xuzhou Mining Group General Hospital

12597939@qq.com+86 17751991669

Outcome results