Alzheimer's disease (AD)
Conditions
Interventions
Experimental group:rTMS stimulation
Control group:rTMS pseudostimulation
Sponsors
Beijing Geriatric Hospital
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Clinically diagnosed or probable AD patients, MMSE score between 10-26 points, and a diagnosis based on head imaging. Disease duration within 10 years. 2. Aged >= 60 years, gender is not limited, and those who can cooperate with rTMS and brain functional magnetic resonance examination have no contraindications. 3. If you are taking AD drugs, you need to take the drug for >=4 weeks, and there is no drug dose adjustment during the treatment period. 4. The patients' guardians agree to participate in this study and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. There are contraindications for transcranial magnetic stimulation: such as those with metal implants such as pacemakers, coronary stents and aneurysm clips, and those with ferromagnetic materials such as cochlear implants; 2. Combined with functional failure and critical illness of important organs (heart, lung, liver, kidney, etc.); 3. Long-term alcoholism and drug abuse; 4. Severe hearing-impaired persons; 5. Those with a history of organic mental illness, infectious diseases, traumatic brain injury and surgery; 6. Those with a history of epilepsy; 7. Those who are undergoing other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Alzheimer's Disease Rating Scale - Cognitive Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini-Mental State Examination Scale;Montreal Cognitive Assessment Scale;Neuropsychiatric Scale;Barthel Index;Resting-state fMRI;Adverse reactions; | — |
Countries
China
Contacts
Public ContactHu Yueqing
Beijing Geriatric Hospital
Outcome results
None listed