Effect of dexmedetomidine on acute kidney injury in elderly patients after laparoscopic partial nephrectomy

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100055100

Enrollment

Unknown

Registered

2021-12-31

Start date

2022-01-04

Completion date

Unknown

Last updated

2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute kidney injury

Interventions

Group 1:Intravenous infusion of dexmedetomidine 0.4 ug/kg/h during surgery

Group 2:Intravenous infusion of normal saline 0.4 ug/kg/h during surgery

Eligibility

Sex/Gender

All

Age

60 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Patients undergoing laparoscopic partial nephrectomy under general anesthesia in our hospital; 2. Aged over 60 years, and the gender is not limited; 3. Preoperative cardiac and renal functions were normal; 4. Voluntarily participate in this experimental study and sign the informed consent.

Exclusion criteria

Exclusion criteria: Received kidney surgery and kidney transplantation before surgery.

Design outcomes

Primary

Measure	Time frame
Serum creatinine;Serum cystatin C;	—

Secondary

Measure	Time frame
Antioxidant response element;Nuclear factor E2-related factor 2;Glutathione peroxidase;Malondialdehyde;Advanced oxidized protein products;	—

Countries

China

Contacts

Public ContactLiu Yongzhe

lyzgao@163.com+86 15811331366

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026