Effects of dexmedetomidine infusion rate on short-term cognitive function after cardiac surgery in elderly patients: a prospective randomized controlled study

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100055093

Enrollment

Unknown

Registered

2021-12-31

Start date

2022-01-01

Completion date

Unknown

Last updated

2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Group L:Intraoperative dexmedetomidine infusion at a low rate (0.1-0.5 µg/kg/h)

Group H:Intraoperative dexmedetomidine infusion at high rate (0.5-0.9 µg/kg/h)

Eligibility

Sex/Gender

All

Age

60 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Aged 60-75 years; 2. Solitary valve surgery; 3. Aortic root surgery.

Exclusion criteria

Exclusion criteria: 1. Ejection fraction <= 50% after admission; 2. Cognitive dysfunction or baseline minimum mental state examination (MMSE) score <= 20 points; 3. Disagree or unable to agree to participate in research and/or unable to speak; 4. Hearing impairment.

Design outcomes

Primary

Measure	Time frame
Mini-Mental State Examination;	—

Secondary

Measure	Time frame
Postoperative delirium;Intraoperative severe hypotension;Intraoperative bradycardia;Hours of initial intubation;Myocardial infarction;Stroke;Cardiac surgery ICU stay;Hospital days;Mortality;	—

Countries

China

Contacts

Public ContactFang Jun

The First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital)

fjjf123@sina.com+86 13170010298

Outcome results