oxidative stress and DNA Damage
Conditions
Interventions
A:Isoflurane alone
B:Isoflurane and Dexmedetomidine infusion
Sponsors
University of veterinary and animal sciences, Lahore, Pakistan
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Male patients aged from 18 to 50 years, will be classified by American Society of Anesthesiology (ASA) with physical status of 1-II (including healthy patients with no existing systemic disease other than surgical abnormality) undergoing invasive emergency surgeries lasting for at least four hours will be included in the study.
Exclusion criteria
Exclusion criteria: Diabetics, Overweight individuals, those with recently intake of antioxidant supplements or any medication, those who received radiation recently and elderly patients with decreased intravascular volume as they are prone to hypotension, will be excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| If Dexmedetomidine is having antioxidant activity, lower level of oxidative stress and DNA damage by the use of Dexmedetomidine infusion with Isoflurane for maintainance of anaethesia will be helpful to overcome these problems during surgery.; | — |
Countries
Pakistan
Contacts
Public ContactDr. Adeel Sattar
University of veterinary and animal sciences
Outcome results
None listed