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Myocardial biomarkers predict cardiotoxicity in lymphoma patients treated with anthracyclines, a multicenter clinical study

Myocardial biomarkers predict cardiotoxicity in lymphoma patients treated with anthracyclines, a multicenter clinical study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100055047
Enrollment
Unknown
Registered
2021-12-31
Start date
2022-01-03
Completion date
Unknown
Last updated
2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lymphoma

Interventions

Case series:None

Sponsors

The First Affiliated Hospital of Dalian Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Histopathological diagnosis of non-Hodgkin's lymphoma for the first time and no history of other malignant tumors; 2. Newly treated non-Hodgkin's lymphoma patients, receiving chemotherapy, the regimen is CHOP±R; 3. Aged 18-80 years; 4. ECOG<=2 points; 5. The expected survival period of the patient is more than 6 months; 6. The baseline meets the indications and basic requirements for chemotherapy; 7. Good compliance and voluntary follow-up.

Exclusion criteria

Exclusion criteria: 1. Pregnant patients; or patients of childbearing age with positive blood/urine pregnancy test, patients of childbearing age and their spouses are unwilling to take effective contraceptive measures during the clinical study and within 6 months after the end; 2. Liposomal doxorubicin drug therapy; 3. Use drug therapy with cardioprotective effect, such as dexrazine, etc.; 4. Patients with severe renal insufficiency, MDRD formula to calculate GFR<15ml/min x min^2 or long-term dialysis patients.

Design outcomes

Primary

MeasureTime frame
Left ventricular ejection fraction;

Secondary

MeasureTime frame
Left chamber longitudinal strain;High-sensitivity troponin T;NT-proBNP;

Countries

China

Contacts

Public ContactXia Yunlong

The First Affiliated Hospital of Dalian Medical University

yunlong_xia@126.com+86 18098875555

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026