Respiratory diseases
Conditions
Interventions
High flow oxygen group:OH-70C (micomme, HuNan, China) will be used to provide HFNC, with flow of 50 L/min and FIO2 at 0.45. The temperature will be set at 37 degree C..
Conventional oxygen therapy group:During the bronchoscopy, the nasal cannula was used for oxygen therapy, and the oxygen inhalation flow was set to 6L/min
Sponsors
Shanghai East Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Hypoxemia with PaO2/FIO2=45 mmHg, baseline chronic lung disease, including COPD, bronchiectasis, etc.; 3. Tracheal stenosis confirmed by radiology before bronchoscopy may be caused by tracheomalacia, tracheal tumor or granuloma, or inhalation of foreign bodies; 4. Morbidly obese patients with body mass index (BMI) >= 30kg/m^2.
Exclusion criteria
Exclusion criteria: 1.Refuse to participate; 2.Local/general anesthesia bronchoscopy or rigid endoscopy is indicated; 3.Aged >= 90 years; 4.Pregnancy; 5.Estimated duration of bronchoscopy is less than 10 minutes; 6.Contraindication to using HFNC, including nasopharyngeal obstruction and blockage; 7.Require oxygen flow = 3L/min to maintain SpO2 at 90-97%; 8.Central airway narrowness >80%; 9.The patient is critically ill and unsuitable for study inclusion assessed by anesthesiologists and pulmonologists.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the incidence of desaturation which is defined as SpO2 < 90% between patients using HFNC and those using COT; | — |
Secondary
| Measure | Time frame |
|---|---|
| the timing of the appearance of the first desaturation;lowest SpO2;highest transcutaneous partial pressure of carbon dioxide;the need for treatment escalation and airway management; the number and duration of bronchoscopy suspensions;the recovery time between the two groups;the incidence of adverse events; | — |
Countries
China
Contacts
Public ContactZhang Wei
Shanghai Changhai Hospital
Outcome results
None listed