White matter injury of prematurity
Conditions
Interventions
Group 1:OPC nasal drip transplantation
Group 2:OPC was injected into lumbar subarachnoid space and transplantation
Sponsors
The Sixth Medical Center of the Chinese People's Liberation Army General Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. 25 weeks <= gestational age < 32 weeks. 2. History or laboratory indicators suggest fetal intrauterine hypoxia or infection. 3. Clinical manifestations: poor response, altered consciousness (excessive excitement, irritability, drowsiness and coma), convulsions, abnormal muscle strength and muscle tone, repeated apnea, etc. 4. aEEG or EEG abnormalities. 5. Brain MRI and/or ultrasound showed abnormal white matter. 6. Informed consent of the legal guardian. 1, 5 and 6 are required conditions, 2 medical history and laboratory must meet at least 1 of these conditions, 3 and 4 must meet one of them.
Exclusion criteria
Exclusion criteria: 1. Uncorrectable serious internal environment disorder or life-threatening. 2. Obstructive hydrocephalus. 3. Systemic coagulation disorders. 4. Major congenital structural deformities, hereditary and metabolic diseases. 5. Intracranial infection, immune deficiency. 6. Patients who are considered by the researchers to be inappropriate to participate in this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NBNA scale and total body exercise assessment; | — |
Countries
China
Contacts
Public ContactLuan Zuo
The Sixth Medical Center of the Chinese People's Liberation Army General Hospital
Outcome results
None listed