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Differential expression of serum microRNA in lean people with nonalcoholic fatty liver disease and the intervention effect of Sijunzi decoction

Differential expression of serum microRNA in lean people with nonalcoholic fatty liver disease and the intervention effect of Sijunzi decoction

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100054996
Enrollment
Unknown
Registered
2021-12-30
Start date
2021-12-31
Completion date
Unknown
Last updated
2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-alcoholic fatty liver disease (NAFLD)

Interventions

Experimental group:Sijunzi Tang Granules

Sponsors

Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Those who signed the informed consent; 2. Aged 18-65 years, gender is not limited; 3. Those who meet the diagnostic criteria of NAFLD in traditional Chinese and Western medicine.

Exclusion criteria

Exclusion criteria: 1. Combined with drug-induced liver injury, autoimmune hepatitis A, B, C, E, etc.; 2. Patients with serious primary diseases of the heart, brain, kidney, lung, endocrine, blood, metabolism and gastrointestinal tract, or mental patients; 3. Creatinine (Cr) is greater than the upper limit of normal; 4. Those who use drugs to lose weight; 5. Alcoholics or drug addicts; 6. Pregnant patients, lactating patients or those who are planning to become pregnant in the near future and those who use estrogen contraception; 7. Allergic constitution and allergic to various drugs, as well as this medicine or the components of this prescription; 8. Those who are in critical condition and it is difficult to make an exact evaluation of the effectiveness and safety of new drugs; 9. The patient is reluctant to collaborate.

Design outcomes

Primary

MeasureTime frame
microRNA;alanine aminotransferase;aspartate aminotransferase;triglycerides;cholesterol;fasting blood sugar;

Countries

China

Contacts

Public ContactYu Xiao

Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine

richhie_xiao@163.com+86 13661956043

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026