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Study on the construction of organoid models derived from tumor patients' malignant effusion and drug sensitivity testing

Study on the construction of organoid models derived from tumor patients' malignant effusion and drug sensitivity testing

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100054986
Enrollment
Unknown
Registered
2021-12-30
Start date
2021-12-30
Completion date
Unknown
Last updated
2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cancer malignant effusion

Interventions

case series:N/A

Sponsors

Affiliated Hangzhou Cancer Hospital, Zhejiang University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: 1.Aged over 18 years; 2.The patient's pathology and immunohistochemical diagnosis and previous treatment (such as anti-tumor therapy, immunotherapy, related surgery, etc.) will not affect the therapeutic effect; 3.Malignant effusion greater than 100ml can be obtained; 4.Cancer cells in the exfoliated cell smear of malignant effusion are positive; 5.There is no clinical diagnosis of other unstable complications or uncontrolled infection; 6.ECOG PS score: 0-2 points; 7.The main organs function normally; 8.Subjects voluntarily participated in this study, signed the informed consent, followed up, and the compliance was good.

Exclusion criteria

Exclusion criteria: 1.Pregnant women and lactating patients; 2.Patients with peripheral nervous system disorders caused by diseases or with a history of obvious mental disorders and central nervous system disorders; 3.Patients with severe infection or active peptic ulcer need treatment; 4.Allergic to chemotherapy drugs.

Design outcomes

Primary

MeasureTime frame
The number and size of organoids;

Countries

China

Contacts

Public ContactZhen Zhang

Affiliated Hangzhou Cancer Hospital, Zhejiang University School of Medicine

zlnszhang@sina.com+86 13858028599

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026