premature ovarian insufficiency
Conditions
Sponsors
Beijing Obstetrics and Gynecology Hospital Affiliated to Capital Medical University
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria of Western medicine for early-onset ovarian insufficiency; 2. Comply with the TCM syndrome differentiation standard of TCM deficiency of qi and blood and deficiency of liver and kidney; 3. Aged >=20 years and < 40; 4. The patient himself gave informed consent and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Ovarian resistance syndrome, reproductive tract dysplasia, polycystic ovary syndrome, hyperprolactinemia, ovarian endometriosis, central nervous system tumors, functional hypothalamic amenorrhea, abnormal thyroid function, abnormal adrenal cortex function and other related symptoms; 2. Pregnant or lactating patients or have a history of miscarriage in the past 1 month; 3. Patients with serious primary diseases of the heart, brain, liver, kidney, hematopoietic and immune systems, blood infectious diseases and mental illness; 4. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) are more than 2 times the upper limit of normal, and serum creatinine (Cr) is greater than the upper limit of normal; 5. Those who have undergone hormone replacement therapy (HRT) and (or) have taken traditional Chinese medicines of nourishing qi and blood, regulating liver and kidney 1 month before enrollment, making it difficult to judge the efficacy of the drugs; 6. Combined with mental disorders, including anxiety disorder (HAMA>=14 points), depression (HAMD>=17 points), etc.; 7. Those who are allergic to the drug components in the known experimental drugs; 8. Participate in other clinical studies within 1 month before screening.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Follicle stimulating hormone; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sex hormone change value;Changes in anti-mullerian hormone;Antral follicle change value;Efficiency of TCM syndrome;Disappearance rate of single symptom;Modified Kupperman score;Changes in Hamilton anxiety scale scores;Hamilton depression scale change values; | — |
Countries
China
Contacts
Public ContactRuan Xiangyan
Beijing Obstetrics and Gynecology Hospital Affiliated to Capital Medical University
Outcome results
None listed