Cardiac function
Conditions
Interventions
Afentanyl group:Afentanyl 20ug/kg
Sufentanil group:Sufentanil 0.32ug/kg
Fentanyl group:Fentanyl 3.2ug/kg
Sponsors
The Second Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Aged 65-90 years; 2. In accordance with the diagnostic criteria of chronic coronary syndrome of the European Heart Association in 2019: refers to the different stages of development of coronary heart disease other than the clinical manifestations dominated by acute coronary thrombosis. Including: (1) Symptoms of suspected coronary heart disease and stable angina pectoris, with or without dyspnea; (2) New heart failure or left ventricular dysfunction, suspected coronary heart disease; (3) Patients with acute coronary syndrome who are asymptomatic or stable within one year of onset, or who undergo revascularization in the near future; (4) With or without symptoms, patients with initial diagnosis or revascularization for more than one year; (5) Patients with angina pectoris, suspected vasospasm or microvascular disease; (6) Asymptomatic patients with coronary heart disease were found during screening; 3. ASA grade II~III; NYHA grade II~III; need general anesthesia; 4. No history of anesthetic allergy; 5. Agreed to participate in this study and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Opioid intolerance; 2. Congenital heart disease, acute coronary syndrome, severe ventricular arrhythmia, atrial fibrillation, severe valvular regurgitation, NYHA grade IV severe heart disease; 3. Severe history of chronic obstructive pulmonary disease (COPD severity III or IV), patients with severe or uncontrolled bronchial asthma, pulmonary infection, bronchiectasis; 4. Identified or suspected abusers of other narcotic analgesics and patients with chronic alcoholism; 5. Morbidly obese (BMI > 30 kg/m^2), with a history of anesthesia within the last 7 days, and known drug allergies; 6. Planned cardiac surgery other conditions; 7. Considered unsuitable for the attending doctor or researcher to participate in this study; 8. Refused to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| GLS (global longitudinal strain); | — |
Secondary
| Measure | Time frame |
|---|---|
| EF (ejection fraction);CO (cardiac output);SV (stroke volume);CCE (cardiac circulation efficiency);CI (cardiac index);Dp/Dt;SVRI (system vascular resistance index);ST segment;ECG;Heart rate;SPO2;Blood pressure; | — |
Countries
China
Contacts
Public ContactHuang He
The Second Affiliated Hospital of Chongqing Medical University
Outcome results
None listed