Perioperative inflammatory response, acute kidney injury
Conditions
Interventions
Experimental group:Continuous infusion of low-dose norepinephrine 0.01-0.1 ug/kg/min combined goal-oriented liquid management to maintain individualized blood pressure
control group:Standard treatment to maintain mean arterial pressure not less than 65 mmHg
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 60-80 years; 2. Undergo elective major open abdominal surgery with an estimated operating time of 2-6 hours; 3. ASA II-III.
Exclusion criteria
Exclusion criteria: 1. Refuse to participate in this study; 2. Patients with previous or preoperative renal insufficiency; 3. Severe liver dysfunction (Child-Pugh grade C); 4. Severe cardiopulmonary insufficiency; 5. History of drug dependence or addiction; 6. Weight less than 50kg or more than 90kg; 7. Admitted to ICU after surgery due to adverse events; 8. Loss to follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TNF-a; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum creatinine;IL-1ß;IL-10;Plasma catecholamines;Blood glucose;Lactose;Length of stay;Mortality; Major complications after surgery(including acute renal injury, delirium and incision infectionect) ;hemodynamic index(MAP,CO,CI,SVV,SVR,PSI,ect);IL-6;ScvO2; | — |
Countries
China
Contacts
Public ContactCheng Xinqi
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed