Multimodal imaging evaluation and pathogenesis research of fetal congenital heart disease

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100054891

Enrollment

Unknown

Registered

2021-12-28

Start date

2022-01-01

Completion date

Unknown

Last updated

2022-12-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fetal congenital heart diseae

Interventions

Feal congenital heart disease group:None

Normal control group:None

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: The specimens of fetuses: 1. Signed informed consent; 2. Donate the fetus specimens voluntarily after the termination of pregnancies in Union Hospital due to fetal congenital heart diseases or other reasons. All subtypes of fetuses with congenital heart disease: 1. Signed informed consent; 2. Commit to abide by the research procedures and cooperate with the implementation of the whole process of the research; 3. Diagnosed or suspected a certain type of congenital heart disease by prenatal echocardiography. Fetuses in the normal control group: 1. Signed informed consent; 2. The gestational age should match the fetuses with congenital heart diseases; 3. Heart structure is normal and checked by echocardiography after birth.

Exclusion criteria

Exclusion criteria: The specimens of fetuses: 1. Donor or legal representative requests to withdraw from clinical research; 2. The donation procedures after induction of labor do not comply with relevant laws and regulations. All fetuses with congenital heart disease: 1. Twin or multiple pregnancies; 2. Intrauterine growth restriction of the fetus; 3. Persistent fetal arrhythmia; 4. Except for a certain type of congenital heart disease with other intracardiac and extracardiac malformations; 5. Maternal diseases and complications of pregnancy (diabetes, hypertension, abnormal thyroid function, etc.). The fetuses in the normal control group: 1. Twin or multiple pregnancies; 2. Abnormal heart rhythm; 3. Extracardiac deformations; 4. Gene and chromosome abnormalities; 5. Maternal diseases and complications of pregnancy (diabetes, hypertension, abnormal thyroid function, etc.).

Design outcomes

Primary

Measure	Time frame
Conventional echocardiographic parameters;Speckle tracking echocardiography parameters;myocardial microstructure parameters of diffusion tensor imaging;	—

Countries

China

Contacts

Public ContactXie Mingxing

Union Hospital, Tongji Medical College, Huazhong University of Science and Tecnology

xiemx@hust.edu.cn+86 13607108938

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026