Postoperative delirium
Conditions
Interventions
Control group:Maintenance of the hemodynamic parameters at ±20 % baseline, PETCO2 at 35-45 mmHg and SpO2 at 94-100%
GDT (Goal-Directed Therapy) group:Maintenance of the rScO2 at ±20% baseline on the basis of the conventional management in control group
Sponsors
Li Huili Hospital of Ningbo Medical Center
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Grade I-II American Society of Anesthesiologists (ASA); 2. Aged 65-85 years; 3. OLV time >= 90 min.
Exclusion criteria
Exclusion criteria: 1. Anemia; 2. Those with important organ dysfunction; 3. Those with inflammation or fever; 4. Those who take psychotropic drugs; 5. Patients who could not coordinate to finish mini-mental state examination (MMSE) or whose scores were lower than the corresponding minimum score (illiteracy ±20% of baseline value or < 55% for more than 15 minutes; 7. Research data loss or midway withdrawal, and perioperative severe complications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the incidence of POD;IL-1ß;IL-6;TNF-a;Lac;S-100ß; | — |
Secondary
| Measure | Time frame |
|---|---|
| the visual analogue score (VAS);awakening time;cases of agitation during awakening;postoperative hospital stays; | — |
Countries
China
Contacts
Public ContactFang Ping
Li Huili Hospital, Ningbo Medical Center
Outcome results
None listed