Prophylactic intra-arterial injection of lidocaine: a novel strategy to prevent endovascular embolization-induced trigeminocardiac reflex

The effect of local injection of lidocaine in cerebrovascular on trigeminal nerve - cardiac reflex in embolization therapy

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100054887

Enrollment

Unknown

Registered

2021-12-28

Start date

2020-06-01

Completion date

Unknown

Last updated

2022-12-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cerebrovascular malformations

Interventions

Lidocaine group:1ml of 2% lidocaine was prophylactically injected into the cerebral artery

Control group :1ml of 0.9% normal saline was prophylactically injected into the cerebral artery

Eligibility

Sex/Gender

All

Age

18 Years to 78 Years

Inclusion criteria

Inclusion criteria: Patients with cerebrovascular malformation were diagnosed and Onyx glue embolization was planned.

Exclusion criteria

Exclusion criteria: 1. Patients with unclear consciousness or inability to provide informed consent and communication difficulties before surgery; 2. Patients with serious cardiovascular diseases; 3. Allergic to any narcotic drug to be studied; 4. History of long-term use of psychotropic drugs; 5. Rejected patients.

Design outcomes

Primary

Measure	Time frame
The incidence of TCR;	—

Secondary

Measure	Time frame
Heart rate, blood pressure, BIS value,complications;Primary disease, complication, embolism;	—

Countries

China

Contacts

Public ContactYouli Hu

The First Affiliated Hospital of Nanjing Medical University/Jiangsu Province Hospital

huyouli@njmu.edu.cn+86 13951996506

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026