orthopedic surgery
Conditions
Interventions
Intravenous acetaminophen group:500 mg intravenous acetaminophen every 6 h for 24 h
Placebo group:the same volume of saline every 6 h for 24 h
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged between 18 and 70 years; 2. were scheduled for major orthopedic surgery under general anesthesia during the enrollment period; 3. had an American Society of Anesthesiologists physical status of I or II; 4. had a body mass index of 18-30 kg/m2; and (e) were able to understand the pain scales and operate an intravenous patient-controlled analgesia (PCA) device.
Exclusion criteria
Exclusion criteria: 1. Contraindications to the study medications; 2. uncontrolled hypertension or diabetes; 3. known history of pulmonary or heart disease; 4. impaired liver function, defined as alanine aminotransferase and/or aspartate aminotransferase more than twice the upper limit of normal, or total bilirubin at least 1.5 times the upper limit of normal; 5. renal dysfunction, defined as creatinine levels > 176 µmol/L in serum; 6. pregnant or 7. at high risk of bleeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| morphine consumption within 24 h after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| pain intensity at rest and during movement at 1, 3, 6, 12, and 24 h postoperatively;the area under the pain intensity-time curve for pain at rest and during movement;how many times the patient pressed the button on the PCA device during the first 24 h postoperatively, and how many times the button-pushing resulted in effective analgesia; | — |
Countries
China
Contacts
Public ContactFei Liu
West China Hospital, Sichuan University
Outcome results
None listed